If you get a chance, stop by St Augustine, it is a beautiful old city and they do it right for Christmas. Disney for the holidays is also something very special whether you go to Disney itself or Epcot, you'll have a good time. Epcot is geared a bit more for adults, in my opinion. If you are golfers, make sure you take your clubs, there are many outstanding courses all over Florida and the Ft Myers areas has some exceptional courses.
If you are driving, be careful when you get around mile mark 305 on I-75. They are widening I-75 and the bridge is a bit of a mess where it goes of 50 - which is the exit I get off from.
Enjoy your Christmas trip.