The wheels on my Camaro get covered with brake dust almost instantly when driving, so keeping my wheels clean is a chore. I use Quick Sealant on my wheels to keep them protected, spraying it on the entire wheel (front, back, and inside of the barrel). I do this once in the spring when the summer wheel/tire combo goes on the car, and once in the fall when the winter wheel/tire combo is put on. Both sets of wheels get the application each time. Then I simply maintain the wheels with Car Shampoo at every wash (use the red wheel brush on the face of the wheel and the wheel woolie on the barrel). Keeping the wheels sealed allows me to skip using the Wheel Cleaner on a regular basis. I only use the Wheel Cleaner when it's time to seal the wheels, so that I know I've stripped the wheels completely.
I haven't noticed my tire cleaning regimen to significantly affect the sealant on the wheels, even when using APC or the new Tire and Rubber Cleaner. If it looks like the sealant is starting to wear down, I can always hit it again with the Quick Sealant since it's so easy to use. Thankfully I stocked up on the Quick Sealant when it was discontinued, so I've got a nice stash to keep me going until Adams releases a new replacement (fingers crossed!!!!).